Chemical name: Terphenyl, chlorinated Final regulatory action has been taken for the category: Industrial Final regulatory action: The chemical is Banned Use or uses prohibited by the final regulatory action: General prohibition of PCT. The use of any preparation with a PCT content of more than 0.005% is prohibited. Use or uses that remain allowed: None The final regulatory action was based on a risk or hazard evaluation: No Summary of the final regulatory action: General prohibition of PCT. The use and import of any preparation with a PCT content of more than 0.005% is prohibited The reasons for the final regulatory action were relevant to: Human health Summary of known hazards and risks to human health: Short-term Toxicity: The liver is the main target organ for PCT, showing increased weight and enzyme induction. Furthermore the eyes and skin are affected (acne-form lesions) and body weight loss is induced. NOEL is above 20 mg/kg bw and below 250 mg/kg bw. Chronic Toxicity: PCTs induce heptocellular carcinomas in mice, lowest effective dose: 250 mg/kg bw (Jensen, 1983). Food: PCT may occur in food at concentrations of 0.01 - 0.05 ppm (Canada). Human daily intake has been estimated at 0.05 /ug (Japan, only vegetable products). Occupational/Use: PCTs have been detected in paper products, paperboard samples contained up to 163 ppm, garbage samples up to 10.5 ppm. Date of entry into force of the final regulatory action: 01/01/2001 |